Preheat oven to 400 degrees with cast iron preheating inside.
Crunch up all crackers in tube into crumbs.
Mix together beef, egg, tomato sauce, salt, pepper, garlic powder, onion powder and crackers in mixing bowl.
Form into a round disc shaped loaf and put into your preheated cast iron skillet.
Make an indention in the middle of your meatloaf to assist with even cooking.
Put the skillet with loaf into oven and bake for 40-45 minutes.
Remove from oven after 45 minutes and add ketchup to top of the meatloaf.
Return to oven for an additional 10-15 minutes and cook until desired doneness. 190-205+/- degrees is preferred.
Let sit for 5 minutes to rest and cool.
Cut, serve and enjoy!